{"id":42792,"date":"2010-06-01T14:06:00","date_gmt":"2010-06-01T14:06:00","guid":{"rendered":"https:\/\/matis.is\/?p=42792"},"modified":"2021-08-23T14:07:27","modified_gmt":"2021-08-23T14:07:27","slug":"ahugaverdur-fyrirlestur-i-husakynnum-matis","status":"publish","type":"post","link":"https:\/\/matis.is\/en\/frettir\/ahugaverdur-fyrirlestur-i-husakynnum-matis\/","title":{"rendered":"An interesting lecture in Mat\u00eds&#039; premises"},"content":{"rendered":"<h4 class=\"wp-block-heading\">Professor Wolfgang Hillen will give a lecture at Mat\u00eds, V\u00ednlandslei\u00f0 12, Reykjav\u00edk on Thursday 3 June at 10.00 - 11.00. The lecture is entitled:&nbsp;<strong>Tetracycline Dependent Gene Regulation in Bacteria and Mammals: From Mechanisms to Applications.&nbsp;<\/strong><\/h4>\n\n\n\n<p>Professor Wolgang Hillen is the Chair of the Department of Microbiology, Friedrich-Alexander University, Erlangen-Nuremberg, Germany.<br><strong>More about the topic of the lecture<\/strong><\/p>\n\n\n\n<p><strong>Tetracycline Dependent Gene Regulation in Bacteria and Mammals: From Mechanisms to Applications<\/strong><br>Tetracycline dependent gene regulation originates from resistance genes against this antibiotic in bacteria. The resistance mechanism has provided evolutionary pressure to establish a gene regulation system with low background expression combined with sensitive and efficient induction. The relevant prokaryotic components have been modified to function in nearly all organisms, including transgenic mice and human cell lines. A special strategy will be described for the construction of a suicide device for gene therapy by inducing apoptosis in human cell lines at will using regulated t-Bid expression. The basal expression is reduced below the induction threshold by a combined repressor \/ activator regulation construct, which leads to over 99% cell death upon induction. Furthermore, a screen for the nuclear localization of proteins will be described that does not need microscopy but instead makes use of a purely genetic procedure in which expression of a reporter gene indicates nuclear localization. The potential for screening novel therapeutics will be discussed.<\/p>\n\n\n\n<p>For further information, please contact Frankl\u00edn Georgsson,&nbsp;<a href=\"mailto:franklin.georgsson@matis.is\">franklin.georgsson@matis.is<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>Pr\u00f3fessor Wolfgang Hillen ver\u00f0ur me\u00f0 fyrirlestur hj\u00e1 Mat\u00eds, V\u00ednlandslei\u00f0 12, Reykjav\u00edk fimmtudaginn 3. j\u00fan\u00ed kl. 10.00 \u2013 11.00. Fyrirlesturinn ber [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":40343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"templates\/template-cover.php","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1973],"tags":[],"class_list":["post-42792","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-frettir"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u00c1hugaver\u00f0ur fyrirlestur \u00ed h\u00fasakynnum Mat\u00eds - Mat\u00eds<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/matis.is\/en\/frettir\/ahugaverdur-fyrirlestur-i-husakynnum-matis\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1hugaver\u00f0ur fyrirlestur \u00ed h\u00fasakynnum Mat\u00eds - Mat\u00eds\" \/>\n<meta property=\"og:description\" content=\"Pr\u00f3fessor Wolfgang Hillen ver\u00f0ur me\u00f0 fyrirlestur hj\u00e1 Mat\u00eds, V\u00ednlandslei\u00f0 12, Reykjav\u00edk fimmtudaginn 3. j\u00fan\u00ed kl. 10.00 \u2013 11.00. 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