Reports

Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties / Isolation, purification and research on blood pressure lowering peptides from fish proteins

Published:

01/12/2009

Authors:

Margrét Geirsdóttir

Supported by:

AVS Fisheries Research Fund

contact

Margrét Geirsdóttir

Project Manager

mg@matis.is

Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties / Isolation, purification and research on blood pressure lowering peptides from fish proteins

The aim of the project was to study the activity of fish peptides and to isolate, purify and define peptides that have an antihypertensive effect. The project set up facilities and knowledge acquired so far by Matis. This includes a method for measuring ACE inhibitory activity as well as peptide isolation and purification equipment. In collaboration with the University of Iceland, HPLC and Maldi-Tof equipment were used to analyze which peptides were in the active components. The results of the project show that Icelandic fish protein could be an important source of peptides with antihypertensive properties. With the knowledge and facilities that have been acquired in the project, it is possible to develop valuable fish products and health food.

The aim of this project was to study the activity of fish proteins and isolate, clarify and define peptides with antihypertensive properties. During the project time methods and equipment to be able to do this were set up at Matis facilities. This includes method to measure ACE inhibition activity as well as filtration and fractionation units to isolate different fractions of peptides. Furthermore, peptides have been identified in the most active fraction by using HPLC and Maldi-ToF equipment in collaboration with the University of Iceland. With this extensive tool box of know-how, equipment and facilities, development of valuable fish products and nutraceuticals from blood pressure-lowering peptides is possible. Thereby the value of the Icelandic natural resources in the sea can be increased.

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